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In contrast, vehicle-treated MIA mice showed no significant change in their sociability scores

As expected, FXR activation with GW4064 at 5 mol/l for 24 h significantly increased FXR target gene expression such as Fgf15 and Ost (data not shown)

Study has demonstrated that GSDMD mediates the shift of tubular cells from apoptosis to pyroptosis in TLR4-regulated diabetic tubular damage, suggesting that GSDMD activation promotes the conversion from non-inflammatory apoptosis to inflammatory pyroptosis (227)

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